BOC RNA provides antisense oligonucleotides (ASOs) synthesis services according to your application to meet the research needs in biology, diagnostics, and drug discovery.
Introduction to Antisense Oligonucleotides
What is ASO
Antisense oligonucleotides are short, synthetic nucleic acid molecules that can be designed to specifically target mRNA molecules and prevent them from being translated into proteins. These molecules have gained a great deal of attention in recent years due to their potential to treat various genetic diseases by targeting disease-causing mutations or controlling overexpression of certain proteins.
What is the Mechanism of Action of ASO
Antisense oligonucleotides work by binding to the target mRNA molecule through complementary base pairing, either by Watson-Crick or Hoogsteen base pairing. This binding can occur in several different ways, such as blocking the ribosome from accessing the mRNA, recruiting RNase H to induce degradation of the mRNA or inhibiting alternative splicing events. The effectiveness of the molecule depends on several factors, including the length and position of the antisense oligonucleotide relative to the target mRNA, the degree of complementarity, and the stability of the resulting duplex structure. The specificity of the antisense oligonucleotide is critical to avoid off-target effects that could cause unintended toxicity and harm.
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Zoe ChengFounder
